4-Repeat Tauopathy Neuroimaging Initiative – Cycle 2 (4RTNI-2)

Observational Study

Get in touch about this study

What is the study about?

This study follows people with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) for up to 2 years and compares their brain changes with healthy volunteers of the same age. Researchers hope to learn more about how patients with PSP and CBD progress over time and which measures are best for tracking change and predicting progression. Various measures including brain imaging, cerebrospinal fluid analysis, eye tracking, blood markers and neuropsychological testing will be measured.


Eligibility– Who can participate?

Participants must:

  • Either have no known history of brain disease (i.e., be a healthy volunteer) or have a diagnosis of corticobasal syndrome or degeneration (CBS or CBD) or progressive supranuclear palsy (PSP)
  • Have a reliable study partner who has frequent contact with participants, can come to study visits and provide information about them
  • Be willing and able to undergo testing procedures and follow-up visits
  • Be able to walk five steps with little help


Time requirement

Participants and their caregivers are asked to come every 6 months for up to 24 months. Visits can be done in-person, remotely or through a combination of remote and in-person (hybrid) visits. Each in-person visit will take 2-3 days to complete. Remote visits via video conference can be completed in 4-5 hours and the hybrid visit will take 4-5 hours of remote and 1 full day of in-person visits. Participants will be reimbursed for the time and expenses incurred with the study visits (travel, parking, food).


TDRA Investigator

Dr. Carmela Tartaglia


More information




Advances in Dementia Research Webinar- Listen to Dr. Carmela Tartaglia (Principal Investigator) discuss the 4RTNI-2 study in further detail. https://youtu.be/WF0qwQAqpM4

TDRA Site:

University Health Network (UHN)-Toronto Western Hospital

Address: 399 Bathurst Street, Toronto ON M5T 2S8

Age Group:

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Target Population:

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Do you have questions about research studies you saw on this page? Please contact tdra@utoronto.ca


The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).