Amyloid and Glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment Patients with Significant White Matter Disease (MITNEC)

Observational Study

Get in touch about this study

What is the study about?

This study is looking at the usefulness of brain imaging, genetic tests, and memory and thinking tasks in identifying and treating white matter disease.  We are looking for participants with Alzheimer’s disease (AD) with white matter disease as well as participants who had a stroke or a Transient Ischemic Attack (TIA).


Eligibility- Who can participate?

Participants must:

  • Have a diagnosis of early Alzheimer’s disease, Mild Cognitive Impairment, OR have had a minor stroke or Transient Ischemic Attack
  • Be 60 years of age or older

Time requirement


6 visits over the course of 2 years, which will involve:

  • 2 MRI scans
  • 1 FDG PET scan
  • 2 AV-45 PET scans
  • Tests for memory, thinking skills, daily functioning, behavior
  • Walking test – short distance 6m
  • One time blood draw at the beginning to the study – 10 ml volume
  • Optional blood draw for genetic testing- 15 ml volume

There will be a baseline visit and a follow up visit after 1 year


TDRA study investigator

Dr. Sandra Black


More information

TDRA Site:

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

Age Group:

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Target Population:

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The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).