MOVE-IT: Efficacy and Safety of N-acetylcysteine (NAC) in Patients With Mild Vascular Cognitive Impairment

What is the study about?

This study looks at whether taking the antioxidant N-acetylcysteine can improve cognitive impairment for people with coronary artery disease and early memory problems, or mild vascular cognitive impairment, while participating in an exercise training program.

 

Eligibility–Who can participate?

Participants must:

• be between 55 and 85 years of age
• have coronary artery disease
• be willing to participate in a 6-month supervised exercise program

 

Time requirement:

9 visits over 24 weeks.

Participants will be asked to give blood samples and perform cognitive tests at three time points. We will also use new techniques to accurately measure the amount of cell damage in blood, and evaluate whether the treatment works better in people with certain brain characteristics on MRI scans.

 

TDRA investigator

Drs. Krista Lanctôt, Nathan Herrmann, Sandra Black

 

More information

https://clinicaltrials.gov/ct2/show/NCT03306979

TDRA Site:

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

Age Group:

55 - 59, 60 - 64, 65 - 69, 70 - 80, 81 - 85

Target Population:

Vascular Cognitive Impairment