MOVE-IT: Efficacy and Safety of N-acetylcysteine (NAC) in Patients With Mild Vascular Cognitive Impairment

Interventional Study

Get in touch about this study

What is the study about?

This study looks at whether taking the antioxidant N-acetylcysteine can improve cognitive impairment for people with coronary artery disease and early memory problems, or mild vascular cognitive impairment, while participating in an exercise training program.


Eligibility–Who can participate?

Participants must:

  • be between 55 and 85 years of age
  • have coronary artery disease
  • be willing to participate in a 6-month supervised exercise program


Time requirement:

9 visits over 24 weeks.

Participants will be asked to give blood samples and perform cognitive tests at three time points. We will also use new techniques to accurately measure the amount of cell damage in blood, and evaluate whether the treatment works better in people with certain brain characteristics on MRI scans.


TDRA investigator

Drs. Krista Lanctôt, Nathan Herrmann, Sandra Black


More information
TDRA Site:

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

Age Group:

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Target Population:

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The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).