Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM)

Treatment Study

Get in touch about this study

What is the study about?

The study examines the safety and effectiveness of antidepressant medications for older adults with difficult-to-treat depression, looking at medication side effects, overall well-being and falls. 


Eligibility- Who can participate?

Participants must:

  • be 60 years of age or older
  • be diagnosed with Current Major Depressive Disorder, single or recurrent
  • have not responded to two or more anti-depressant treatment trials of recommended dose and length (approximately 12 weeks)


Time requirement

10 bi-weekly phone calls and 5 in-person visits (or 10 phone calls if unable to attend in person) over 17 months


TDRA study investigators
Drs. Benoit Mulsant, Krista Lanctot


More information


TDRA Site:


Address: 3560 Bathurst St, North York, ON M6A 2E1

Centre for Addiction and Mental Health (CAMH)

Address: 1001 Queen St W, Toronto, ON M6J 1H4

St. Michael’s Hospital

Address: 209 Victoria St, Toronto, ON M5B 1T8

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

University Health Network (UHN)-Toronto General Hospital

Address: 200 Elizabeth St, Toronto, ON M5G 2C4

Age Group:

, , , , ,

Target Population:

Do you have questions about research studies you saw on this page? Please contact tdra@utoronto.ca


The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).