Full study title: Transcranial Alternating Current Stimulation and Focused Ultrasound to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients with Mild Cognitive Impairment
What is the study about?
This study is looking at using two new non-invasive brain stimulations methods called transcranial alternating current stimulation (tACS) and focused ultrasound (FUS) to see if they can improve working memory and thinking processes in people with Mild Cognitive Impairment (MCI).
tACS is a low-risk, non-painful, low electrical current that circulates through the brain of awake participants and stimulates their brain cells. FUS is another low-risk, non-painful, and non-invasive intervention to stimulate the brain cells similar tACS but is using MRI-guided ultrasound to accurately target the brain area of interest.
Eligibility- Who can participate?
- Be 60 years of age or older
- Have a diagnosis of mild cognitive impairment
Participants will undergo treatment sessions that range from 1 to 1.5 hours at CAMH or Sunnybrook, 5 days a week, over a total of 3 weeks. In addition, participants will complete clinical and cognitive assessments and bloodwork at baseline and again after treatment
TDRA study investigator
Dr. Tarek Rajji
Centre for Addiction and Mental Health (CAMH)
Address: 1001 Queen St W, Toronto, ON M6J 1H4Sunnybrook Health Sciences Centre