Interventional Study

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Full study title: Transcranial Alternating Current Stimulation and Focused Ultrasound to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients with Mild Cognitive Impairment


What is the study about?

This study is looking at using two new non-invasive brain stimulations methods called transcranial alternating current stimulation (tACS) and focused ultrasound (FUS) to see if they can improve working memory and thinking processes in people with Mild Cognitive Impairment (MCI).


tACS is a low-risk, non-painful, low electrical current that circulates through the brain of awake participants and stimulates their brain cells. FUS is another low-risk, non-painful, and non-invasive intervention to stimulate the brain cells similar tACS but is using MRI-guided ultrasound to accurately target the brain area of interest.


Eligibility- Who can participate?

Participants must:

  • Be 60 years of age or older
  • Have a diagnosis of mild cognitive impairment


Time requirement

Participants will undergo treatment sessions that range from 1 to 1.5 hours at CAMH or Sunnybrook, 5 days a week, over a total of 3 weeks. In addition, participants will complete clinical and cognitive assessments and bloodwork at baseline and again after treatment


TDRA study investigator

Dr. Tarek Rajji

TDRA Site:

Centre for Addiction and Mental Health (CAMH)

Address: 1001 Queen St W, Toronto, ON M6J 1H4

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

Age Group:

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Target Population:

Do you have questions about research studies you saw on this page? Please contact tdra@utoronto.ca


The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).