Targeting Brain Physiology to Treat Neuropsychiatric Symptoms in Dementia using TMS-EEG and tDCS (tTED)

Interventional Study

Get in touch about this study

What is the study about?

This study aims to better understand and treat agitation in patients with Alzheimer’s disease using non-invasive brain stimulation. The brain stimulation approaches being used are transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS).



Eligibility- Who can participate?

Participants must:

  • Be over 50 years of age
  • Have a diagnosis of Alzheimer’s disease, with or without agitation


Time requirement

All participants will complete baseline assessments, one session of TMS brain stimulation with brain wave monitoring (using EEG) and an optional MRI brain scan. Participants with agitation will also be enrolled in 10 treatment sessions with tDCS brain stimulation (5 days/week, 30 minutes/day, for 2 weeks). These participants will then undergo TMS brain stimulation and complete clinical and cognitive assessments after treatment and again 2 weeks later.


TDRA study investigator

Dr. Sanjeev Kumar


More information

TDRA Site:

Centre for Addiction and Mental Health (CAMH)

Address: 1001 Queen St W, Toronto, ON M6J 1H4

Age Group:

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Target Population:

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The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).