What is the study about?
This study aims to better understand and treat agitation in patients with Alzheimer’s disease using non-invasive brain stimulation. The brain stimulation approaches being used are transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS).
Eligibility- Who can participate?
- Be over 50 years of age
- Either have a diagnosis of Alzheimer’s disease, with or without agitation, or be a healthy volunteer
All participants will complete baseline assessments, one session of TMS brain stimulation with brain wave monitoring (using EEG) and an optional MRI brain scan. Participants with agitation will also be enrolled in 10 treatment sessions with tDCS brain stimulation (5 days/week, 30 minutes/day, for 2 weeks). These participants will then undergo TMS brain stimulation and complete clinical and cognitive assessments after treatment and again 2 weeks later.
TDRA study investigator
Dr. Sanjeev Kumar
Centre for Addiction and Mental Health (CAMH)
Address: 1001 Queen St W, Toronto, ON M6J 1H4