Investigating whether psilocybin can improve memory in persons with mild cognitive impairment
Interventional Study
Get in touch about this studyFull study title: Does psilocybin change synaptic vesicular density in the brains of patients with mild cognitive impairment
What is the study about?
This study will explore whether a psychedelic called psilocybin may help improve memory by increasing connections in the brain. In the study, participants will be randomly assigned to receive either psilocybin or a placebo. There will also be brain scans and cognitive tests.
Eligibility – Who can participate?
Participants must:
- Be 60-75 years of age
- Have a diagnosis of mild cognitive impairment, or have subjective memory decline or concerns about memory changes
- Have no past psychedelic use
- Not be taking medications for dementia or depression
Time requirement
The study will consist of 9 visits across 12 weeks, for a total of about 41 hours.
- Visit 1: Screening (about 2-3 hours)
- Visit 2: Neuropsychological testing (about 2-3 hours)
- Visit 3: MRI Scan (about 1 hour)
- Visits 4 and 7: PET Scans (about 2-3 hours/visit)
- Visit 5 and 6: Psilocybin or placebo treatment (about 7 hours/visit)
- Visit 8 and 9: Follow-up (about 3-4 hours)
TDRA study investigators
Dr. Philip Gerretsen
More information
https://www.camh.ca/en/science-and-research/research-connect/investigating-the-effect-of-psilocybin-on-the-brain-activity-of-individuals-reb-101-2021
TDRA Site:
Centre for Addiction and Mental Health (CAMH)
Address: 1001 Queen St W, Toronto, ON M6J 1H4