Exercise as a Primer for Excitatory Stimulation Study in Vascular Cognitive Impairment No Dementia (EXPRESS-V)

Interventional Study

Get in touch about this study

What is the study about?

People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS), a type of brain stimulation, is believed to work best on brain cells that are active or “primed” before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.


Eligibility–Who can participate?

Participants must:

  • Be 50 years of age or older, females must be post-menopausal
  • Presence of cerebrovascular and/or cardiovascular risk factors or coronary artery disease
  • Proficient in English
  • Able to exercise at a moderate intensity level

Time requirement:

There is a minimum of 3 study assessments and 2 MRI visits over the course of approximately 9 weeks. There is a screening/baseline visit, endpoint visit and a 1-month post-study endpoint visit. In these 3 visits, blood is drawn and a cognitive battery is administered. If randomized to an exercise group, participants will exercise at Toronto Rehab every weekday for 2 consecutive weeks and receive tDCS following each exercise session. If participant is not randomized to an exercise group, their tDCS sessions will be held at Sunnybrook every weekday for 2 consecutive weeks.


TDRA investigator

Dr. Krista Lanctôt, Dr. Nathan Herrmann,  Dr. Tarek Rajji,  Dr. Sandra Black


More information

TDRA Site:

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

Age Group:

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Target Population:


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The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).