Genetic Frontotemporal Dementia Initiative (GENFI)

What is the study about?

This study looks at people aged 18 and older who either are at risk or have symptoms of frontotemporal dementia caused by genetics. By monitoring participants over time, researchers hope to find ways to diagnose frontotemporal dementia, understand how the disease develops, find new treatments and monitor outcomes.

 

 

Eligibility- Who can participate?

Participants must be:

• 18 years of age or older
• a member of a family with a known genetic mutation that causes frontotemporal dementia (i.e., mutations in the granulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9ORF72) genes)

 

Time requirement

Once a year for 3+ years. The visits will include undergoing brain imaging, cognitive testing, and taking blood samples

 

TDRA Study Investigator

Dr. Mario Masellis

TDRA Site:

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

Age Group:

18 - 24, 25 - 29, 30 - 39, 40 - 49, 50 - 54, 55 - 59, 60 - 64, 65 - 69, 70 - 80, 81 - 85, 86 - 90, 91+

Target Population:

Family history of Frontotemporal dementia (FTD)