Personalized Prediction of Neurodegenerative Outcomes

Observational Study

Get in touch about this study

Full study title: Improving prognostic confidence in neurodegenerative diseases causing dementia using peripheral biomarkers and integrative modeling

 

What is the study about?

This study aims to improve diagnostic accuracy of neurodegenerative diseases and figuring out how they might progress. The study will do this by looking at your blood, results of cognitive questionnaires and information from a clinical checkup. It’s often hard to get the diagnosis right for diseases causing dementia, and predicting progression is difficult. It’s important to get the right diagnosis quickly so that the right treatments and supports can be offered. A lumbar puncture and skin biopsy are optional and can be used to measure proteins related to neurodegenerative diseases.

 

Eligibility – Who can participate?

Participants must:

  • Have a diagnosis of mild cognitive impairment (MCI) or dementia
  • Be 30 to 95 years of age
  • Have a study partner who has some weekly contact with you and can answer questions regarding your memory and functioning

 

Time requirement

3 visits over 1 year. Study visits occur every 6 months and include questionnaires, blood collection, and optional procedures such as a lumbar puncture and a skin biopsy.

 

TDRA study investigators

Drs. Carmela Tartaglia, David Tang-Wai, Morris Freedman, Ekaterina Rogaeva, Dan Felsky, Sanjeev Kumar, Sandra Black, and Tarek Rajji

 

More information

Toronto Dementia Research Alliance (TDRA) Coordinated Studies List: TDRA Coordinated Studies | Dementia Research (utoronto.ca)

TDRA Site:

Sunnybrook Health Sciences Centre

Address: 2075 Bayview Ave, Toronto, ON M4N 3M5

University Health Network (UHN)-Toronto Western Hospital

Address: 399 Bathurst Street, Toronto ON M5T 2S8

Age Group:

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Disclaimer

The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).