Treatment of Comorbid Depression and Cognitive Impairment in Older Adults with Neurocognitive Disorders Using Deep Transcranial Magnetic Stimulation (dTMS)

What is the study about?

This study looks at how effective a brain stimulation technique called deep Transcranial Magnetic Stimulation (dTMS) is in treating depression in patients with Alzheimer’s disease or mild cognitive impairment who have failed to respond to antidepressant medications. We also evaluate if dTMS affects memory and other cognitive abilities. The study may involve neuroimaging and electroencephalography (EEG) to examine how dTMS affects brain activity.

 

Eligibility- Who can participate?

Participants must:

• Be 60 years of age or older
• Have a diagnosis of both Major Depressive Disorder (MDD) and Alzheimer’s disease (AD), or MDD and mild cognitive impairment (MCI)

Time requirement

Participants will complete physical and neurological examinations at the screening visit. Participants will undergo treatment sessions that range from 1 to 1.5 hours at Baycrest, 5 days a week, over a total of 4 weeks. In addition, participants will undergo depression questionnaires and memory testing at baseline, after treatment, and again 4 weeks later.

 

TDRA study investigator

Dr. Linda Mah

 

More information

https://clinicaltrials.gov/ct2/show/NCT03665831

TDRA Site:

Baycrest

Address: 3560 Bathurst St, North York, ON M6A 2E1

Age Group:

60 - 64, 65 - 69, 70 - 80, 81 - 85, 86 - 90, 91+

Target Population:

Alzheimer’s disease, Major Depressive Disorder, Mild cognitive impairment