Treatment of Comorbid Depression and Cognitive Impairment in Older Adults with Neurocognitive Disorders Using Deep Transcranial Magnetic Stimulation (dTMS)

Interventional Study

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What is the study about?

This study looks at how effective a brain stimulation technique called deep Transcranial Magnetic Stimulation (dTMS) is in treating depression in patients with Alzheimer’s disease or mild cognitive impairment who have failed to respond to antidepressant medications. We also evaluate if dTMS affects memory and other cognitive abilities. The study may involve neuroimaging and electroencephalography (EEG) to examine how dTMS affects brain activity.


Eligibility- Who can participate?

Participants must:

  • Be 60 years of age or older
  • Have a diagnosis of both Major Depressive Disorder (MDD) and Alzheimer’s disease (AD), or MDD and mild cognitive impairment (MCI)

Time requirement

Participants will complete physical and neurological examinations at the screening visit. Participants will undergo treatment sessions that range from 1 to 1.5 hours at Baycrest, 5 days a week, over a total of 4 weeks. In addition, participants will undergo depression questionnaires and memory testing at baseline, after treatment, and again 4 weeks later.


TDRA study investigator

Dr. Linda Mah


More information

TDRA Site:


Address: 3560 Bathurst St, North York, ON M6A 2E1

Age Group:

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Target Population:

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The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).