CT Radiation Study

Interventional Study

Get in touch about this study

Full study title: Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Dementia (LDIR-CT-Dementia) Trial: A Pilot Study


What is the study about?

This study is a randomized control trial that is trying to find out whether the radiation from repeated CT scans can temporarily improve the functioning, memory, thinking, and/or behaviour in people with advanced dementia. A CT scan sends out a low dose of radiation. In this study, depending on the group a participant is placed in and how long they participate, a participant could receive up to eight CT scans over several weeks.


Eligibility- Who can participate?

Participants must:

  • Be in advanced stage of dementia (the study team will do a short assessment to determine eligibility)
  • Have a study partner who can also participate; the study partner will play an important role and must be someone who regularly spends time with the participant—at least several times a week
  • Have been clinically stable for the last 3 months


Time requirement

  • There are two phases that are 13 weeks each. If you choose to participate in both phases, it is 26 weeks in total. Study visits are approximately once a week (but there are some breaks with no activity for three weeks). In addition to CT scans, participants will also undergo cognitive testing, blood draws, and electroencephalography (EEG).


TDRA study investigator

Dr. Morris Freedman

TDRA Site:


Address: 3560 Bathurst St, North York, ON M6A 2E1

Age Group:

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Target Population:

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Do you have questions about research studies you saw on this page? Please contact tdra@utoronto.ca


The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).