Multimodal Assessment for Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration

Observational Study

Get in touch about this study

What is the study about?

This study aims to evaluate different tests such as brain imaging, skin biopsy, eye tracking, blood and spinal fluid analysis, clinical and cognitive assessments and determine which of these tests work best in the diagnosis of Frontotemporal Lobar Degeneration (FTLD). This information will be used to help us understand why and how FTLD occurs and guide future diagnosis and treatment.



Eligibility–Who can participate?

Patients and Healthy volunteers who satisfy the following:

  • Be 18 to 90 years of age
  • Patient participants will need a reliable study partner who can provide information on the participant’s behavior, thinking and functioning. Healthy volunteers will not be required to have a study partner.
  • Be able to read, understand and speak English for neuropsychological testing
  • Either be a healthy volunteer or have a diagnosis of:
    • Frontotemporal dementia (FTD)
    • Corticobasal syndrome (CBS)
    • Progressive supranuclear palsy (PSP)
    • Primary progressive aphasia (PPA)


Time requirement: 2 full days during which the following assessments are performed:

  • MRI brain scan
  • PET brain scan
  • Blood draw
  • Eye scanning
  • Skin biopsy
  • Spinal tap
  • Clinical assessment – medical history, physical and neurological exam
  • Neuropsychological testing
  • Study partner questions for patient participants


TDRA investigator

Dr. Carmela Tartaglia


More information

TDRA Site:

University Health Network (UHN)-Toronto Western Hospital

Address: 399 Bathurst Street, Toronto ON M5T 2S8

Age Group:

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Target Population:

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The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).