Toronto Dementia Research Alliance - Affiliated

Research Studies

Find, review and get in touch about research studies in Toronto from the comfort of your home

Most Recent Research Studies

CAnnabidioL Medication Intervention Trial (CALM-IT)

Interventional Study

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Alzheimer’s disease

Sunnybrook Health Sciences Centre

What is the study about? This study will look at how cannabidiol (CBD) can help control symptoms of agitation in persons living with Alzheimer’s disease (AD). The CBD-based medication that…

CUE-D

Observational Study

18 - 2425 - 2930 - 3940 - 4950 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Mild cognitive impairment

Mild Dementia

Moderate Dementia

Parkinson's disease-related dementia

Subjective cognitive decline

Vascular dementia

Participate from home

Full study title: A Cueing System Co-Created with Individuals Living with Dementia to Maintain Independence in Daily Activities (CUE-D): A Proof-of-Concept Project   What is the study about? This study…

CIRCA Study

Observational Study

18 - 2425 - 2930 - 3940 - 4950 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Caregivers

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Mild cognitive impairment

Mild Dementia

Moderate Dementia

Parkinson's disease-related dementia

Subjective cognitive decline

Vascular dementia

Participate from home

Full study title: CIRCA: A Canadian Version of the Computer Interactive Reminiscing and Conversation Aid   What is the study about? The goal of this study is to develop and…

Investigating whether psilocybin can improve memory in persons with mild cognitive impairment

Interventional Study

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Mild cognitive impairment

Subjective cognitive decline

Centre for Addiction and Mental Health (CAMH)

Full study title: Does psilocybin change synaptic vesicular density in the brains of patients with mild cognitive impairment   What is the study about? This study will explore whether a…

Personalized Prediction of Neurodegenerative Outcomes

Observational Study

30 - 3940 - 4950 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Corticobasal Syndrome (CBS)

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Mild cognitive impairment

Parkinson's disease-related dementia

Vascular dementia

Sunnybrook Health Sciences CentreUniversity Health Network (UHN)-Toronto Western Hospital

Full study title: Improving prognostic confidence in neurodegenerative diseases causing dementia using peripheral biomarkers and integrative modeling   What is the study about? This study aims to improve diagnostic accuracy…

tACS

Interventional Study

60 - 6465 - 6970 - 8081 - 8586 - 9091+

Mild cognitive impairment

Centre for Addiction and Mental Health (CAMH)

Full study title: Transcranial Alternating Current Stimulation to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients with Mild Cognitive Impairment What is the study about? This study is looking…

Bright Spark

Observational Study

60 - 6465 - 6970 - 8081 - 85

Alzheimer’s disease

Mild cognitive impairment

Baycrest

Full study title: Bright Spark: Measuring Brain Activity to Predict Cognitive Health in MCI & Alzheimer’s Disease   What is the study about? This study looks at how the brain’s…

Virtual Reality (VR) Training Program for Dementia Caregivers

Observational Study

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Caregivers

Dementia Researchers

Expert on dementia caregiving

Virtual reality technology expert

Participate from homeRoadshow locations

Full study title: Dementia Caregivers Skill Training Through Virtual Reality Simulation (VR-SIM Carers)   What is the study about? “VR-SIM Carers” aims to adapt a caregiver training program for dementia…

Task Sequencing & Dementia Study

Observational Study

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Alzheimer’s disease

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Healthy volunteer

Mild cognitive impairment

Mild Dementia

Moderate Dementia

Parkinson's disease-related dementia

Vascular dementia

Toronto Rehab Institute-University Health Network

Full study title:Understanding Task Sequencing in People with Mild Cognitive Impairment (MCI) and Dementia to Inform the Use of Mixed Reality   What is the study about? The goal of…

In-vehicle technology: Decision aid for driving with dementia

Observational Study

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Alzheimer’s disease

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Healthy volunteer

Mild cognitive impairment

Mild Dementia

Parkinson's disease-related dementia

Vascular Cognitive Impairment

Vascular dementia

BaycrestSunnybrook Health Sciences Centre

Full study title: Using mobile technology to inform driving decision-making in dementia   What is the study about? This study will assess if a Driving Monitoring System installed in participant’s…

Bootle Blast & Dementia Study

Interventional Study

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Alzheimer’s disease

Caregivers

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Mild cognitive impairment

Parkinson's disease-related dementia

Vascular Cognitive Impairment

Vascular dementia

Participate from home

Full study title: Feasibility-Testing of a Youth Therapeutic Exercise Video Game System (‘Bootle Blast’) with Older Adults with Dementia   What is the study about? This study looks at how…

IBHeC-short

Observational Study

60 - 6465 - 6970 - 8081 - 8586 - 9091+

Healthy volunteer

Healthy volunteer with a past history of depression that was treated

Mild cognitive impairment

Mild cognitive impairment with a past history of depression that was treated

Subjective cognitive decline

Baycrest

Full study title: Investigating the Brain-Heart Connection-short version   What is the study about? The goal of the study is to examine the relationship between heart rhythms and memory or…

CT Radiation Study

Interventional Study

40 - 4950 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Lewy Body Dementia (LBD)

Parkinson's disease dementia

Vascular dementia

Baycrest

Full study title: Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Dementia (LDIR-CT-Dementia) Trial: A Pilot Study   What is the study about? This study is…

Virtual Assessment of Praxis as a Novel Predictor of Activities of Daily Living in Dementia

Observational Study

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Alzheimer’s disease

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Mild cognitive impairment

Mild Dementia

Moderate Dementia

Parkinson's disease-related dementia

Vascular dementia

Participate from home

What is the study about? This study will assess a person’s ability to perform pretend movements, like pretending to comb your hair or brush your teeth. This assessment will be…

CAnadian Multi-Ethnic Research on Aging (CAMERA) study

Observational Study

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Caregivers

Healthy volunteer

Sunnybrook Health Sciences Centre

What is the study about? This study is looking at risk and protective factors for dementia in three of Canada’s largest ethnic groups: individuals who identify as East Asian, South…

Photobiomodulation (light therapy) for amnestic mild cognitive impairment (aMCI)

Interventional Study

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Mild cognitive impairment

St. Michael’s Hospital

What is the study about? This study is looking at using a form of non-invasive light therapy called photobiomodulation as a treatment for amnestic Mild Cognitive Impairment (aMCI), which is…

FRONSTIM

Interventional Study

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Frontotemporal dementia (FTD)

University Health Network (UHN)-Toronto Western Hospital

Full Study Title:  Subgenual Cingulate Deep Brain STIMulation for Apathetic Behavioral Variant FRONtotemporal Dementia (FRONSTIM)   What is the study about? This is a 3-year study designed to evaluate the…

Music Listening Study

Observational Study

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Mild cognitive impairment

Baycrest

Full Study Title:  The effects of a listening program of autobiographically salient music on cognitive measures and underlying neural mechanisms in mild cognitive impairment: An EEG study   What is…

rTMS Apathy Clinical Trial (REACT)

Interventional Study

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Alzheimer’s disease

Frontotemporal dementia (FTD)

Vascular dementia

Sunnybrook Health Sciences Centre

What is the study about? Apathy is a common, early, and disabling symptom in dementias such as Alzheimer’s disease (AD) and is characterized by lack of interest and enthusiasm. Both…

Investigating the Brain-Heart Connection

Observational Study

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Healthy volunteer

Major Depressive Disorder

Mild cognitive impairment

Baycrest

What is the study about? The goal of the study is to examine the relationship between heart rhythms and memory or mood symptoms in older adults. Previous studies have shown…

Effect of Deep Transcranial Magnetic Stimulation (dTMS) on Cognition in Older Adults with Subjective Cognitive Decline (SCD)

Interventional Study

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Family history of Alzheimer's disease

Subjective cognitive decline

Baycrest

What is the study about? The purpose of this study is to examine the effect of cognitive training combined with a brain stimulation technique called Deep Transcranial Magnetic Stimulation (dTMS)…

Treatment of Comorbid Depression and Cognitive Impairment in Older Adults with Neurocognitive Disorders Using Deep Transcranial Magnetic Stimulation (dTMS)

Interventional Study

60 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Major Depressive Disorder

Mild cognitive impairment

Baycrest

What is the study about? This study looks at how effective a brain stimulation technique called deep Transcranial Magnetic Stimulation (dTMS) is in treating depression in patients with Alzheimer’s disease…

Development of a Novel Behavioural Intervention to Improve Emotional Well-Being in Older Adults

Interventional Study

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Healthy volunteer

Baycrest

What is the study about? This study looks at whether older adults can reduce stress levels by participating in a novel intervention that involves breathing techniques done at home. The…

Examining knowledge of risk factors for dementia among adults in Canada

Observational Study

18 - 2425 - 2930 - 3940 - 4950 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Frontotemporal dementia (FTD)

Healthy volunteer

Lewy Body Dementia (LBD)

Mild cognitive impairment

Parkinson's disease dementia

Parkinson's disease-related dementia

Vascular Cognitive Impairment

Vascular dementia

Participate from home

What is the study about? The goal of this study is to assess what adults in Canada know, and importantly, do not know, about risk factors for dementia. We are…

Exercise as a Primer for Excitatory Stimulation Study in Vascular Cognitive Impairment No Dementia (EXPRESS-V)

Interventional Study

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Mild cognitive impairment

Vascular Cognitive Impairment

Sunnybrook Health Sciences Centre

What is the study about? People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has…

Exercise Augmenting Cognition tDCS (EXACT): A Pilot Study of a Combined Exercise and Transcranial Direct Current Stimulation Intervention for Cognition

Interventional Study

50 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Mild cognitive impairment

Sunnybrook Health Sciences Centre

What is the study about? This study looks at whether combining physical exercise with electrical currents applied to the brain (transcranial direct current stimulation) can help improve memory in people…

Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Observational Study

18 - 2425 - 2930 - 3940 - 4950 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Corticobasal Syndrome (CBS)

Family history of Frontotemporal dementia (FTD)

Frontotemporal dementia (FTD)

Primary Progressive Aphasia (PPA)

Progressive Supranuclear Palsy (PSP)

University Health Network (UHN)-Toronto Western Hospital

What is the study about? This is a 5-year study which aims to evaluate and characterize frontotemporal lobar degeneration (FTLD) patients and asymptomatic individuals belonging to family with a strong…

Enhancing Frontal Lobes Plasticity and Function in Patients with Mild Cognitive Impairment (PAS-MCI)

Interventional Study

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Healthy volunteer

Mild cognitive impairment

Centre for Addiction and Mental Health (CAMH)

What is the study about? This study is assessing the use of a novel brain stimulation technique called Transcranial Magnetic Stimulation to determine if it can improve memory and thinking…

A Pilot Study Assessing the Benefits of a Dementia Caregiver Educational Brochure on Decreased Empathy and Emotion Recognition in Patients with Neurodegenerative Disease

Observational Study

50 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Caregivers

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Parkinson’s disease

Vascular dementia

University Health Network (UHN)-Toronto Western Hospital

What is the study about? This study evaluates an educational brochure tailored to caregivers of people with Alzheimer’s disease, Parkinson’s disease dementia, Lewy body disease, frontotemporal dementia, and vascular disease…

Brain-Eye Amyloid Memory (BEAM) Study

Observational Study

50 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 90

Alzheimer’s disease

Dementia with Lewy bodies (DLB)

Frontotemporal dementia (FTD)

Lewy Body Dementia (LBD)

Parkinson’s disease

Vascular Cognitive Impairment

Centre for Addiction and Mental Health (CAMH)Sunnybrook Health Sciences CentreUniversity Health Network (UHN)-Toronto Western Hospital

What is the study about? This study is investigating whether measurements of the eye can be used with other tests to detect dementia earlier. By comparing the results of non-invasive…

Nabilone for Agitation Blinded Intervention Trial (NAB-IT)

Interventional Study

55 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Centre for Addiction and Mental Health (CAMH)Ontario Shores Centre for Mental Health SciencesSt. Michael’s HospitalSunnybrook Health Sciences Centre

What is the study about? This study will look at nabilone as a treatment for agitation in persons with Alzheimer’s disease (AD).  Nabilone is approved by Health Canada for managing…

Multimodal Assessment for Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration

Observational Study

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Corticobasal Syndrome (CBS)

Frontotemporal dementia (FTD)

Healthy volunteer

Primary Progressive Aphasia (PPA)

Progressive Supranuclear Palsy (PSP)

University Health Network (UHN)-Toronto Western Hospital

This study aims to evaluate different tests such as brain imaging, skin biopsy, eye tracking, blood and spinal fluid analysis, clinical and cognitive assessments and determine which of these tests…

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer’s Disease Caused by a Genetic Mutation (DIAN-TU)

Interventional Study

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People with Alzheimer's disease genes

Sunnybrook Health Sciences Centre

This study examines people with no cognitive difficulties, mild cognitive impairment or Alzheimer’s disease who have genetics that causes Alzheimer’s disease. The goal is to test the safety and effectiveness…

Mind-Matter Interactions and the Frontal Lobes of the Brain

Observational Study

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Stroke

Unilateral Frontal Lobe Damage

Baycrest

What is the study about? This study explores whether people with damage to the front of their brain can use their mind to influence their surroundings (displaying what are known…

Genetic Frontotemporal Dementia Initiative (GENFI)

Observational Study

18 - 2425 - 2930 - 3940 - 4950 - 5455 - 5960 - 6465 - 6970 - 8081 - 8586 - 9091+

Family history of Frontotemporal dementia (FTD)

Sunnybrook Health Sciences Centre

This study looks at people aged 18 and older who either are at risk or have symptoms of frontotemporal dementia caused by genetics. By monitoring participants over time, researchers hope…

Investigating the abilities of people with dementia to take over driving control in conditionally automated vehicles

Observational Study

65 - 6970 - 8081 - 8586 - 9091+

Alzheimer’s disease

Frontotemporal dementia (FTD)

Healthy volunteer

Lewy Body Dementia (LBD)

Mild cognitive impairment

Mild Dementia

Parkinson’s disease

Subjective cognitive decline

Vascular dementia

Toronto Rehab Institute-University Health Network

This study is interested in learning how people with dementia and/or Mild Cognitive Impairment (MCI) handle self-driving cars. By understanding what people may find useful or hard about self-driving cars,…

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Do you have questions about research studies you saw on this page? Please contact tdra@utoronto.ca or call 416-795-0929

Disclaimer

The listing of a study on the Toronto Dementia Network (TDN) is for informational purposes only. The safety, efficacy or scientific validity of the studies listed here have not been evaluated by The Alzheimer Society of Toronto (AST) or the Toronto Dementia Research Alliance (TDRA). The TDRA is an academic coalition among the University of Toronto and four memory clinics across Toronto at Baycrest, the Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre, and the University Health Network. The information collected will be kept and guarded by TDRA. Choosing to participate in a study is an important personal decision. Before you participate in a study, you should make sure you understand the risks and potential benefits and discuss all options with your health care provider(s).